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Publication: C-type lectin receptors in asthma
Hadebe, S ; Brombacher, F ; Brown, G.D
Hadebe, S
Brombacher, F
Brown, G.D
Abstract
Asthma is a heterogeneous disease that affects approximately 300 million people worldwide, largely in developed countries. The etiology of the disease is poorly understood, but is likely to involve specific innate and adaptive responses to inhaled microbial components that are found in allergens. Fungal-derived allergens represent a major contributing factor in the initiation, persistence, exacerbation, and severity of allergic asthma. C-type lectin like receptors, such as dectin-1, dectin-2, DC-specific intercellular adhesion molecule 3-grabbing nonintegrin, and mannose receptor, recognize many fungal-derived allergens and other structurally similar allergens derived from house dust mites (HDM). In some cases, the fungal derived allergens have been structurally and functionally identified alongside their respective receptors in both humans and mice. In this review, we discuss recent understanding on how selected fungal and HDM derived allergens as well as their known or unknown receptors shape allergic airway diseases.
Description
Date
2018-04-11
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers
Collections
Research Projects
Organizational Units
Journal Issue
Keywords
C-type lectin receptors,Allergens,Dectin-1,Fungi,Sensitization,Good health and well-being
Citation
Hadebe S, Brombacher F, Brown GD. C-Type Lectin Receptors in Asthma. Front Immunol. 2018 Apr 11;9:733. doi: 10.3389/fimmu.2018.00733.