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Publication: Clinical and molecular epidemiology of invasive group B streptococcus disease among infants, China
Ji, W Liu, H Madhi, S.A Cunnington, M Zhang, Z Dangor, Z Zhou, H Mu, X Jin, Z Wang, A
Ji, W
Liu, H
Madhi, S.A
Cunnington, M
Zhang, Z
Dangor, Z
Zhou, H
Mu, X
Jin, Z
Wang, A
Abstract
Invasive group B Streptococcus (GBS) remains a leading cause of illness and death among infants globally. We conducted prospective and retrospective laboratory-based surveillance of GBS-positive cultures from infants <3 months of age in 18 hospitals across China during January 1, 2015-December 31, 2017. The overall incidence of GBS was 0.31 (95% CI 0.27-0.36) cases/1,000 live births; incidence was 0-0.76 cases/1,000 live births across participating hospitals. The case-fatality rate was 2.3%. We estimated 13,604 cases of GBS and 1,142 GBS-associated deaths in infants <90 days of age annually in China. GBS isolates were most commonly serotype III (61.5%) and clonal complex 17 (40.6%). Enhanced active surveillance and implementation of preventive strategies, such as maternal GBS vaccination, warrants further investigation in China to help prevent these infections.
Description
Date
2019-11
Journal Title
Journal ISSN
Volume Title
Publisher
Centers for Disease Control Prevention
Collections
Research Projects
Organizational Units
Journal Issue
Keywords
Group B Streptococcus,Bacteria,Clonal complex,Epidemiology,Incidence,Infants,Sequence type,Streptococci
Citation
Ji W, Liu H, Madhi SA, Cunnington M, Zhang Z, Dangor Z, Zhou H, Mu X, Jin Z, Wang A, Qin X, Gao C, Zhu Y, Feng X, She S, Yang S, Liu J, Lei J, Jiang L, Liu Z, Li G, Li Q, Deng Q, Gao K, Fang Y. Clinical and Molecular Epidemiology of Invasive Group B Streptococcus Disease among Infants, China. Emerg Infect Dis. 2019 Nov;25(11):2021-2030. doi: 10.3201/eid2511.181647.