Publication:
The exercise, arterial modulation and nutrition in youth South Africa study (ExAMIN Youth SA)

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dc.contributor.authorKruger, R.
dc.contributor.authorMonyeki, M.A.
dc.contributor.authorSchutte, A.E.
dc.contributor.authorSmith, W.
dc.contributor.authorMels, C.M.C.
dc.contributor.authorKruger, H.S.
dc.contributor.authorPienaar, A.E.
dc.contributor.authorGafane-Matemane, L.F.
dc.contributor.authorBreet, Y.
dc.contributor.authorLammertyn, L.
dc.contributor.authorMokwatsi, G.G.
dc.contributor.authorKruger, A.
dc.contributor.authorDeacon, E.
dc.contributor.authorHanssen. H.
dc.contributor.departmentRuan Kruger, Aletta Elisabeth Schutte, Wayne Smith: MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa.en_US
dc.date.accessioned2024-03-21T16:03:20Z
dc.date.available2024-03-21T16:03:20Z
dc.date.epub2020
dc.date.issued2020-04-29
dc.description.abstractBackground: The impact of a sedentary and unhealthy lifestyle on cardiovascular health is well-documented, however the current obesity and hypertension trends among children is concerning. The ExAMIN Youth SA study aims to investigate the impact of lifestyle behaviors (physical fitness/activity, dietary intake and psychosocial factors) involved in early vascular aging among South African children. Methods: This study is an analytical, multidisciplinary, observational cohort study in a school-based setting. We aim to phenotype a cohort of ~1,000 primary school children (black and white boys and girls between ages 5-9 years) based on current clinical childhood conditions including hypertension and obesity. The primary phenotype is large artery stiffness and retinal microvascular diameters, both biomarkers of early vascular aging. The risk factors and mediators of early vascular aging and also responsible for the clinical conditions include physical inactivity, unhealthy diet, and life stress. Additionally, urinalysis and salivary analyses will be performed to identify biomarkers related to the pathophysiology of early vascular aging. Discussion: In line with the growing prevalence of obesity and hypertension responsible for the development of early vascular aging from childhood to adulthood, this study will address the critical areas in which we observe unfavorable arterial modulation related to dietary behaviors, physical inactivity, and early life stress. Implementation of novel biological markers may further contribute to our understanding of early cardiovascular adaptations in childhood, and aid in the development of primary prevention programs.en_US
dc.description.sponsorshipThe research funded in this manuscript is part of an ongoing research project financially supported by the South African Medical Research Council (SA MRC) Extra Mural Unit and the National Research Foundation (NRF) of South Africa for Competitive Support for Y-Rated Researchers (Unique IdentificationNumber:112141)andtheNRFEquipmentRelated Training and Travel Grant (Unique Identification Number: 109905). Research reported in this paper was supported by the South African Medical Research Council under a SelfInitiated Research Grant. Additionally, we would like to thank International Atomic Energy Agency (IAEA) for financial support.
dc.identifier.citationKruger R, Monyeki MA, Schutte AE, Smith W, Mels CMC, Kruger HS, Pienaar AE, Gafane-Matemane LF, Breet Y, Lammertyn L, Mokwatsi GG, Kruger A, Deacon E, Hanssen H. The Exercise, Arterial Modulation and Nutrition in Youth South Africa Study (ExAMIN Youth SA). Front Pediatr. 2020 Apr 29;8:212. doi: 10.3389/fped.2020.00212.en_US
dc.identifier.doihttps://doi.org/10.3389/fped.2020.00212
dc.identifier.journalFrontiers in Pediatricsen_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/32411640/
dc.identifier.urihttps://doi.org/10.3389/fped.2020.00212
dc.identifier.urihttps://hdl.handle.net/11288/595589
dc.language.isoenen_US
dc.publisherFrontiersen_US
dc.research.unitHypertension and Cardiovascular Diseaseen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectChild health
dc.subjectBlood pressure
dc.subjectObesity
dc.subjectArterial stiffness
dc.subjectRetinal vessel diameters
dc.subjectNutrition
dc.subjectPhysical activity
dc.subjectPsychosocial behavior
dc.titleThe exercise, arterial modulation and nutrition in youth South Africa study (ExAMIN Youth SA)en_US
dc.typeArticleen_US
dspace.entity.typePublication
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