Publication: Perinatally acquired HIV infection accelerates epigenetic aging in South African adolescents
Horvath, S Stein, D.J Phillips, N Heany, S.J Kobor, M.S Lin, D.T.S Myer, L Zar, H.J Levine, A.J Hoare, J
Horvath, S
Stein, D.J
Phillips, N
Heany, S.J
Kobor, M.S
Lin, D.T.S
Myer, L
Zar, H.J
Levine, A.J
Hoare, J
Abstract
Objective
Recent studies demonstrate that infection with the Human Immunodeficiency Virus-1 (HIV) is associated with accelerated aging effects in adults according to a highly accurate epigenetic biomarker of aging known as epigenetic clock. However, it not yet known whether epigenetic age acceleration occurs as early as adolescence in perinatally HIV-infected (PHIV+) youth.
Design
Observational study of PHIV and HIV-uninfected adolescents enrolled in the Cape Town Adolescent Antiretroviral Cohort (CTAAC) Study.
Methods
The Illumina EPIC array was used to generate blood DNA methylation data from 204 PHIV and 44 age-matched, uninfected (HIV-) adolescents aged 9 to 12 years old. The epigenetic clock software and method was used to estimate two measures of epigenetic age acceleration. Each participant completed a comprehensive neuropsychological test battery upon enrolment to CTAAC.
Results
HIV is associated with biologically older blood in PHIV+ adolescents according to both measures of epigenetic age acceleration. One of the measures, extrinsic epigenetic age acceleration, is negatively correlated with measures of cognitive functioning (executive functioning, working memory, processing speed).
Conclusions
Overall, our results indicate that epigenetic age acceleration in blood can be observed in PHIV+ adolescents and that these epigenetic changes accompany poorer cognitive functioning.
Description
Date
2018-07-17
Journal Title
Journal ISSN
Volume Title
Publisher
Wolters Kluwer
Collections
Research Projects
Organizational Units
Journal Issue
Keywords
HIV,DNA methylation,Biomarker,Aging,Perinatal HIV,Epigenetic clock,SDG-03 Good health and well-being
Citation
Horvath S, Stein DJ, Phillips N, Heany SJ, Kobor MS, Lin DTS, Myer L, Zar HJ, Levine AJ, Hoare J. Perinatally acquired HIV infection accelerates epigenetic aging in South African adolescents. AIDS. 2018 Jul 17;32(11):1465-1474. doi: 10.1097/QAD.0000000000001854.