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Publication: Drug-resistant tuberculosis: Challenges and opportunities for diagnosis and treatment
Koch, A Cox, H Mizrahi, V
Koch, A
Cox, H
Mizrahi, V
Abstract
With an estimated incidence of 490000 cases in 2016, multidrug resistant tuberculosis (TB), against which key first-line anti-tuberculars are less efficacious, presents major challenges for global health. Poor treatment outcomes coupled with a yawning treatment gap between those in need of second-line therapy and those who receive it, underscore the urgent need for new approaches to tackle the scourge of drug-resistant TB. Against this background, significant progress has been made in understanding the complex biology of TB drug resistance and disease pathogenesis, and in establishing a pipeline for delivering new drugs and drug combinations. In this review, we highlight the challenges of drug-resistant TB and the ways in which new advances could be harnessed to improve treatment outcomes.
Description
Date
2018-06-06
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Publisher
Elsevier
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Research Projects
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Keywords
Drug-resistant tuberculosis,Global health,Treatment,TB,SDG-03 Good health and well-being
Citation
Koch A, Cox H, Mizrahi V. Drug-resistant tuberculosis: challenges and opportunities for diagnosis and treatment. Curr Opin Pharmacol. 2018 Oct;42:7-15. doi: 10.1016/j.coph.2018.05.013