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Publication: Comparison of amplicor and GeneXpert MTB/RIF tests for diagnosis of tuberculous meningitis.
Patel, Vinod B Connolly, Cathy Singh, Ravesh Lenders, Laura Matinyenya, Brian Theron, Grant Ndung'u, Thumbi Dheda, Keertan
Patel, Vinod B
Connolly, Cathy
Singh, Ravesh
Lenders, Laura
Matinyenya, Brian
Theron, Grant
Ndung'u, Thumbi
Dheda, Keertan
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Abstract
There are no data about the comparative accuracy of commercially available nucleic acid amplification tests (GeneXpert MTB/RIF and Roche Amplicor) for the diagnosis of tuberculous meningitis (TBM). A total of 148 patients with suspected TBM were evaluated, and cultures served as the reference standard. The sensitivities and specificities (95% confidence interval [CI]) for the Amplicor and Xpert MTB/RIF tests were similar: 46 (31-60) versus 50 (33-67) and 99 (93-100) and 94 (84-99), respectively.
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2014-10
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Keywords
Tuberculous Meningitis,Diagnosis,GeneXpert MTB/RIF,Roche Amplicor,accuracy
Citation
Comparison of amplicor and GeneXpert MTB/RIF tests for diagnosis of tuberculous meningitis. 2014, 52 (10):3777-80 J. Clin. Microbiol.