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Publication: HPV infection and the genital cytokine milieu in women at high risk of HIV acquisition
Liebenberg, J.P McKinnon, L.R Yende-Zuma, N Garrett, N Baxter, C Kharsany, A.B.M Archary, D Rositch, A Samsunder, N Mansoor, L.E
Liebenberg, J.P
McKinnon, L.R
Yende-Zuma, N
Garrett, N
Baxter, C
Kharsany, A.B.M
Archary, D
Rositch, A
Samsunder, N
Mansoor, L.E
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Abstract
Human papillomavirus (HPV) infection correlates with higher rates of HIV acquisition, but the underlying biological mechanisms are unclear. Here we study associations between HPV and HIV acquisition and relate these to vaginal cytokine profiles in an observational cohort of women at high risk of HIV infection (CAPRISA 004, nā=ā779) and with 74% HPV prevalence. We report here that HPV infection associates with a 2.5-fold increase in HIV acquisition risk in this population (95% CI: 1.2ā5.3). Among 48 vaginal cytokines profiled, cytokines associated with HPV infection overlap substantially with cytokines associated with HIV risk, but are distinct from those observed in HPV negative women. Although our data do not establish a causative link between HPV status and the risk of HIV, we suggest that increasing HPV vaccination coverage may carry an additional benefit of reducing the risk of contracting HIV infection, particularly in regions with high HPV prevalence.
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Date
2019-11-19
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Publisher
Springer Nature
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Keywords
HPV infection,Women,HIV,Human papillomavirus (HPV),vaginal cytokine,Genitals
Citation
Liebenberg LJP, McKinnon LR, Yende-Zuma N, Garrett N, Baxter C, Kharsany ABM, Archary D, Rositch A, Samsunder N, Mansoor LE, Passmore J-AS, Abdool Karim SS, Abdool Karim Q. HPV infection and the genital cytokine milieu in women at high risk of HIV acquisition. Nature Communications. 2019;10(1):5227. DOI: 10.1038/s41467-019-13089-2.