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Intra-Mural Research Outputs
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The SAMRC’s Intramural Units are the organisation’s internal research divisions which employ specialist scientists from various fields to conduct laboratory investigations, clinical research and public health studies. The Intramural Units focus their research on the leading causes of death in South Africa which include Tuberculosis (TB), HIV, Non-communicable Diseases like cardiovascular disease, and diabetes, along with alcohol and drug abuse, among others. Women’s health is another key focus area. Research conducted by the SAMRC’s Intramural Units has provided the South African government and National Department of Health with information and insights needed for health planning and assessments.
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Differential expression of glycoprotein IV on monocyte subsets following high-fat diet feeding and the impact of short-term low-dose aspirin treatment
(Elsevier, 2020-08-01)Objective: To assess the levels of glycoprotein GPIV (CD36) expression on peripheral blood monocyte subsets, in a mouse model of glucose intolerance. Moreover, to determine the effect of; low-dose aspirin (LDA) alone, LDA ... -
Identification of potential biomarkers for predicting the early onset of diabetic cardiomyopathy in a mouse model
(Nature Publishing Group, 2020-07-23)Type 2 diabetes (T2D) is characterized by metabolic derangements that cause a shift in substrate preference, inducing cardiac interstitial fibrosis. Interstitial fibrosis plays a key role in aggravating left ventricular ... -
Health worker experiences of and perspectives on engaging men in HIV care: A qualitative study in Cape Town, South Africa
(SAGE, 2020-05-29)Men generally fare worse than women across the HIV cascade. While we know much about how men perceive the health services, we know little about how health workers (HWs) themselves have experienced engaging with men and ... -
The effectiveness of peer and community health worker-led self-management support programs for improving diabetes health-related outcomes in adults in low-and-middle-income countries: A systematic review
(BMC, 2020-06-06)Objective: Community-based peer and community health worker-led diabetes self-management programs (COMP-DSMP) can benefit diabetes care, but the supporting evidence has been inadequately assessed. This systematic review ... -
Unspoken inequality: How COVID-19 has exacerbated existing vulnerabilities of asylum-seekers, refugees, and undocumented migrants in South Africa
(BMC, 2020-08-20)An estimated 2 million foreign-born migrants of working age (15-64) were living in South Africa (SA) in 2017. Structural and practical xenophobia has driven asylum-seekers, refugees, and undocumented migrants in SA to ... -
Linking LOXL2 to cardiac interstitial fibrosis
(MDPI, 2020-08-18)Cardiovascular diseases (CVDs) are the leading causes of death worldwide. CVD pathophysiology is often characterized by increased stiffening of the heart muscle due to fibrosis, thus resulting in diminished cardiac function. ... -
Role of vaccines in preventing influenza in healthy children
(HMPG, 2021-03-02)The role of an influenza vaccine is to minimise illness and death. Vaccines provide good protection against influenza strains and significantly reduce time off work. However, the recommendation for use depends on the ... -
Inter-Comparison Campaign of Solar UVR Instruments under Clear Sky Conditions at Reunion Island (21◦S, 55◦E)
(MDPI, 2020-04-19)Measurement of solar ultraviolet radiation (UVR) is important for the assessment of potential beneficial and adverse impacts on the biosphere, plants, animals, and humans. Excess solar UVR exposure in humans is associated ... -
Association of deworming with reduced eosinophilia: implications of HIV/AIDS and co-endemic diseases
(2003)Eosinophil counts in venous blood were monitored during a randomized controlled deworming trial (n = 155 children) that lasted for a year, and in a whole-school deworming programme (range 174-256 children) of 2 years' ... -
Fumonisin mycotoxins in human hair
(2003)This study shows for the first time the accumulation of fumonisin mycotoxins in human hair of population clusters exposed to contaminated maize, and thus the feasibility of human hair analysis for the assessment of past ... -
Influence of the G2 cell cycle block abrogator pentoxifylline on the expression and subcellular location of cyclin B1 and p34(cdc2) in HeLa cervical carcinoma cells
(1999)Abstract. The progression of cells from G2 into mitosis in mainly controlled by formation of the cyclin B1/p34cdc2 complex. The behavior of this complex in the irradiation-induced G2 cell cycle delay is still unclear. A ... -
The MRC/Wits dental research Institute: its publication record 1954-2004.
(Academy of Science for South Africa, 2006)All 625 scientific papers published by the Dental Research Institute (DRI) during its life between 1954 and 2004 were examined and categorized according to publishing journal, article content and author, with the aim of ... -
Interleukin‐6 Inhibitor, Tocolizumab, for COVID‐19: evidence review of the clinical benefit and harm
(South African National Department of Health, 2020-04-15) -
Lopinavir–ritonavir (LPV/r) for treatment of COVID‐19: evidence review of clinical benefits and harms
(South African National Department of Health, 2020-04-22) -
Azithromycin for COVID‐19: evidence review of the clinical benefit and harm
(South African National Department of Health , 2020-05-11) -
Favipiravir for the prevention and management of COVID‐19: evidence review of the clinical benefit and harm
(South African National Department of Health, 2020-06-25) -
Corticosteroids for COVID‐19: evidence review of the ckinical benefit and harm
(South African National Department of Health, 2020-07-23) -
Remdesivir for COVID‐19: evidence review of the clinical benefit and harm
(South African National Department of Health , 2020-06-24) -
Chloroquine and hydroxychloroquine for prevention of COVID‐19: evidence review of clinical benefits and harm
(South African National Department of Health, 2020-06-18) -
Continuing Low Colon Cancer Incidence in African Populations
(Elsevier, 2000)