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dc.contributor.authorGey van Pittius, N.C.
dc.contributor.authorSampson, S.L.
dc.contributor.authorWarren, R.M.
dc.contributor.authorVan Helden, P.D.
dc.identifier.citationWarren R.M., Sampson S.L., Van Helden P.D., Gey van Pittius N.C. Genome variation in Mycobacterium tuberculosis : pathogen genomics. South African Journal of Scienceen_US
dc.description.abstractGenome variation is the main underlying reason for phenotypic differences observed between organisms from the same species. This includes minor variations like single nucleotide polymorphisms, but also large sequence polymorphisms due to deletions and insertions. Some of these variations are of insignificant functional importance, but others may lead to an increase in viability and, in the case of microbes, possibly an increase in pathogenicity. However, the influence of variations on phenotype is not always dependent on the size of the mutated domain, and even single nucleotide polymorphisms can cause significant changes in an organism. This is of course an important area of research into studying pathogenic organisms and their epidemiological features. Mycobacterium tuberculosis</I> strains also display a degree of strain variation, which has been previously suggested to be important for the outcome of disease. Certain strains are postulated to be more or less virulent, persistent, transmissible, or immunopathological. These variations do not only have important implications for the spread of the disease, but provide us with tools to characterize transmission, which have been used extensively for a number of years in tuberculosis molecular epidemiology. In this article, we discuss the different methods which are available for detecting genome variation; we look at the different mechanisms which cause this variation (including insertions, deletions, duplications and single nucleotide polymorphisms), and review the consequences and implications of this genome variation with regard to Mycobacterium tuberculosis pathogenicity..en_US
dc.publisherAcademy of Science for South Africaen_US
dc.rightsAttribution 3.0 United States*
dc.subjectGenome variationen_US
dc.subjectMycobacterium tuberculosisen_US
dc.subjectgenome variationen_US
dc.titleGenome variation in mycobacterium tuberculosisen_US
dc.contributor.departmentUS/MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, Faaculty of Health Science, Stellenbosch University, Tygerburg 7505, South Africaen_US
dc.identifier.journalSouth African Journal of Scienceen_US
dc.research.unitClosed Unitsen_US

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Attribution 3.0 United States
Except where otherwise noted, this item's license is described as Attribution 3.0 United States