Loading...
Maternal traditional dietary pattern and antiretroviral treatment exposure are associated with neonatal size and adiposity in urban, black South Africans
Wrottesley, S.V ; Ong, K.K ; Pisa, P.T ; Norris, S.A
Wrottesley, S.V
Ong, K.K
Pisa, P.T
Norris, S.A
Citations
Altmetric:
Abstract
This study examines the associations between maternal Traditional dietary pattern adherence and HIV/treatment with neonatal size and adiposity in urban, black South Africans, as well as how specific maternal factors - that is BMI and gestational weight gain (GWG) - may influence these associations. Multiple linear regression models were used to examine associations among maternal Traditional diet pattern adherence (pattern score), HIV/treatment status (three groups: HIV negative, HIV positive (antenatal antiretroviral treatment (ART) initiation), HIV positive (pre-pregnancy ART initiation)), BMI and GWG (kg/week), and newborn (1) weight:length ratio (WLR, kg/m) in 393 mother-neonate pairs, and (2) Peapod estimated fat mass index (FMI, kg/m3) in a 171-pair subsample. In fully adjusted models, maternal obesity and GWG were associated with 0·25 kg/m (P=0·008) and 0·48 kg/m (P=0·002) higher newborn WLR, whereas Traditional diet pattern score was associated with lower newborn WLR (-0·04 kg/m per +1 sd; P=0·033). In addition, Traditional diet pattern score was associated with 0·13 kg/m3 (P=0·027) and 0·32 kg/m3 (P=0·005) lower FMI in the total sample and in newborns of normal-weight women, respectively. HIV-positive (pre-pregnancy ART) v. HIV-negative (ref) status was associated with 1·11 kg/m3 (P=0·002) higher newborn FMI. Promotion of a Traditional dietary pattern, alongside a healthy maternal pre-conception weight, in South African women may reduce newborn adiposity and metabolic risk profiles. In HIV-positive women, targeted monitoring and management strategies are necessary to limit treatment-associated effects on in utero fat deposition.
Description
Date
2018-09
Journal Title
Journal ISSN
Volume Title
Publisher
Cambridge University Press
Collections
Research Projects
Organizational Units
Journal Issue
Keywords
ADP air displacement plethysmography,ART antiretroviral treatment,DXA dual-energy X-ray absorptiometry,FMI fat mass index,GWG gestational weight gain,QFFQ quantitative FFQ,WLR weight:length ratio,Antiretroviral treatment,Neonatal adiposity,Pregnancy,South Africa,Traditional dietary patterns
Citation
Wrottesley SV, Ong KK, Pisa PT, Norris SA. Maternal traditional dietary pattern and antiretroviral treatment exposure are associated with neonatal size and adiposity in urban, black South Africans. Br J Nutr. 2018 Sep;120(5):557-566. doi: 10.1017/S0007114518001708.