A systematic review of molecular autopsy studies in sudden infant death cases

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Date
2018-8-18
Authors
Martin, L
Ramesar, R
Heathfield, L
Journal Title
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Volume Title
Publisher
Thieme
Abstract
Sudden unexpected death is an upsetting event, which can remain unexplained even after post-mortem investigation. Internationally, molecular autopsies have shown to resolve up to 44% of unexplained cases; however, it is currently unclear how many of these were infants. This systematic literature review showed that significantly fewer infant cases were resolved (median: 4%) compared with cohorts of 1 to 45 years old (median: 32%). Further, no study involving indigenous African participants has yet been published. Overall, molecular autopsies hold immense value to living family members and is motivation to explore new avenues in infant cohorts.
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Citation
Heathfield LJ, Martin LJ, Ramesar R. A Systematic Review of Molecular Autopsy Studies in Sudden Infant Death Cases. J Pediatr Genet. 2018 Dec;7(4):143-149. doi: 10.1055/s-0038-1668079
URI
https://pubmed.ncbi.nlm.nih.gov/30430032/
 https://hdl.handle.net/11288/597940
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Extramural: Journal Articles