Loading...
Publication: The neurocognitive profile of post-traumatic stress disorder (PTSD), major depressive disorder (MDD), and PTSD with comorbid MDD
Koopowitz, S.M. Mare, K.T. Zar, H.J. Stein, D.J. Ipser, J.C.
Koopowitz, S.M.
Mare, K.T.
Zar, H.J.
Stein, D.J.
Ipser, J.C.
Citations
Altmetric:
Abstract
Objective
Neurocognitive dysfunction has been associated with postātraumatic stress disorder (PTSD) and major depressive disorder (MDD). However, although PTSD is often comorbid with MDD, there is little neurocognitive work to date on individuals who suffer from both PTSD and MDD. Here, we compared neurocognitive domains in individuals with PTSD, MDD, and comorbid PTSD and MDD with those of healthy controls.
Methods
Participants comprised of mothers enrolled in the Drakenstein Child Health Study, a study exploring child health determinants in the Drakenstein district, Western Cape. N = 175 mothers (between 18 and 50 years) were recruited and divided into 4 groups: PTSD, MDD, PTSD with MDD, and healthy controls. Participants were assessed using the computerized NIH Toolbox, and paper and pencil neurocognitive tests. Domains assessed included executive function, memory, attention, learning, and processing speed.
Results
Distinct patterns of neurocognitive dysfunction were observed in this sample. PTSD was associated with more intrusion errors and MDD was associated with delayed recall impairment, relative to healthy controls. PTSD with comorbid MDD was associated with processing speed impairments, relative to healthy controls, and monodiagnostic groups. No group differences were observed on measures of attention and executive function.
Conclusion
Distinct patterns of neurocognitive dysfunction were associated with diagnoses of MDD and PTSD. Greater anticipated dysfunction and impairment in comorbid PTSD and MDD was not observed, however. Further work is needed to replicate and extend these findings.
Description
Date
2021-04
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Collections
Research Projects
Organizational Units
Journal Issue
Keywords
PTSD,Depression,Cognition,Cognitive dysfunction,Comorbidity
Citation
Koopowitz SM, MarƩ KT, Zar HJ, Stein DJ, Ipser JC. The neurocognitive profile of post-traumatic stress disorder (PTSD), major depressive disorder (MDD), and PTSD with comorbid MDD. Brain Behav. 2021 Apr;11(4):e01950. doi: 10.1002/brb3.1950. Epub 2021 Mar 5.