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Protocol for systematic review and meta-analysis of sex hormones and diabetes risk in ageing men and women of African ancestry
Kufe, N.C Masemola, M Chikowore, T Kengne, A.P Olsson, T Goedecke, J.H Micklesfield, L.K
Kufe, N.C
Masemola, M
Chikowore, T
Kengne, A.P
Olsson, T
Goedecke, J.H
Micklesfield, L.K
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Abstract
Methods We shall conduct a comprehensive search of published studies that examined the association between sex hormones and type 2 diabetes risk in men and women aged ≥40 years from 01/01/1980 to 31/03/2018 with no language restriction. Databases to be searched include: PubMed, Scopus, Cochrane Library, Cumulative Index to Nursing and Allied Health, ISI Web of Science, Clinical Trial registries, Google Scholar and institutional websites such as the WHO, American Diabetes Association, International Diabetes Federation, World Diabetes Foundation, European Association for the Study of Diabetes, African Journal Online and ProQuest databases. This protocol is developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guidelines. Independent screening for eligible studies using defined criteria and data extraction, will be completed in duplicate. Discrepancies will be resolved by consensus or consultation with a third researcher. Risk of bias of included studies will be assessed by the appropriate Cochrane risk of bias tool. The overall association estimates will be pooled using appropriate meta-analytic techniques. Heterogeneity will be assessed using Cochrane Q statistic and the inconsistency index (I2). The random effects model will be used to calculate a pooled estimate.
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Date
2019-01-03
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BMJ
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Keywords
epidemiology,general endocrinology,general medicine (see internal medicine)
Citation
Kufe NC, Masemola M, Chikowore T, Kengne AP, Olsson T, Goedecke JH, Micklesfield LK. Protocol for systematic review and meta-analysis of sex hormones and diabetes risk in ageing men and women of African ancestry. BMJ Open. 2019 Jan 3;9(1):e024446. doi: 10.1136/bmjopen-2018-024446.