SAFE pathway and conditioning: from discovery to its effectiveness in the presence of cardiovascular risk factors

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dc.contributor.authorImamdin, A.
dc.contributor.authorHadebe, N.
dc.contributor.authorLecour, S.
dc.contributor.departmentSouth African Medical Research Council, Cape Town, South Africaen_US
dc.date.accessioned2023-12-11T11:47:01Z
dc.date.available2023-12-11T11:47:01Z
dc.date.epub2020-04
dc.date.issued2020-05-05
dc.description.abstractAlthough ischemic conditioning has been described as the most powerful strategy to protect against ischemia-reperfusion injury, its translation to the clinical setting has proved to be challenging, possibly due, at least in part, to the presence of different cardiovascular risk factors in patients, which are known to affect its efficacy. Ischemic conditioning confers cardioprotection via the activation of multiple prosurvival pathways, including the activation of the survivor activating factor enhancement (SAFE) path, which involves mediators of the innate immune system (i.e. tumor necrosis factor alpha) and key transcription factors such as the signal transducer and activator of transcription 3 (STAT3). Here, we describe the origin of the SAFE path as a key pathway in ischemic conditioning and we explore how the activation of this path may be affected in the presence of different cardiovascular risk factors.en_US
dc.description.sponsorshipThe research of SL is supported by the University of Cape Town and the National Research Foundation (111801), The Cancer Association of South Africa and Winetech. AI received a postdoctoral fellowship from the University of Cape Town and NH received a PhD fellowship from the Medical Research Council in South Africa.en_US
dc.identifier.citationAqeela Imamdin1, Nkanyiso Hadebe1,2, Sandrine Lecour1SAFE pathway and conditioning: from discovery to its effectiveness in the presence of cardiovascular risk factors Conditioning Medicineen_US
dc.identifier.journalConditioning Medicineen_US
dc.identifier.urihttps://infospace.mrc.ac.za/handle/11288/595312
dc.language.isoenen_US
dc.publisherOpen accessen_US
dc.relation.url10.1007/s00395-018-0670-5en_US
dc.research.unitCardiometabolic Healthen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectProsurvival signalling pathwaysen_US
dc.subjectSAFEen_US
dc.subjectTumor Necrosis Factoren_US
dc.subjectsignal transducer and activator of transcription 3en_US
dc.subjectcardiovascular risk factorsen_US
dc.titleSAFE pathway and conditioning: from discovery to its effectiveness in the presence of cardiovascular risk factorsen_US
dc.typeArticleen_US
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