Neuroimaging young children and associations with neurocognitive development in a South African birth cohort study

dc.contributor.authorWedderburn, C.J.
dc.contributor.authorSubramoney, S.
dc.contributor.authorYeung, S.
dc.contributor.authorFouche, J.P.
dc.contributor.authorJoshi, S.H.
dc.contributor.authorNarr, K.L.
dc.contributor.authorRehman, A.M.
dc.contributor.authorRoos, A.
dc.contributor.authorIpser, J.
dc.contributor.authorRobertson, F.C.
dc.contributor.authorGroenewold, N.A.
dc.contributor.authorGibb, D.M.
dc.contributor.authorZar, H.J.
dc.contributor.authorStein, D.J.
dc.contributor.authorDonald, K.A.
dc.contributor.departmentAnnerine Roos: SU/UCT MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, South Africaen_US
dc.date.accessioned2024-03-22T19:45:50Z
dc.date.available2024-03-22T19:45:50Z
dc.date.epub2020-04-15
dc.date.issued2020-10
dc.description.abstractMagnetic resonance imaging (MRI) is an indispensable tool for investigating brain development in young children and the neurobiological mechanisms underlying developmental risk and resilience. Sub-Saharan Africa has the highest proportion of children at risk of developmental delay worldwide, yet in this region there is very limited neuroimaging research focusing on the neurobiology of such impairment. Furthermore, paediatric MRI imaging is challenging in any setting due to motion sensitivity. Although sedation and anesthesia are routinely used in clinical practice to minimise movement in young children, this may not be ethical in the context of research. Our study aimed to investigate the feasibility of paediatric multimodal MRI at age 2-3 years without sedation, and to explore the relationship between cortical structure and neurocognitive development at this understudied age in a sub-Saharan African setting. A total of 239 children from the Drakenstein Child Health Study, a large observational South African birth cohort, were recruited for neuroimaging at 2-3 years of age. Scans were conducted during natural sleep utilising locally developed techniques. T1-MEMPRAGE and T2-weighted structural imaging, resting state functional MRI, diffusion tensor imaging and magnetic resonance spectroscopy sequences were included. Child neurodevelopment was assessed using the Bayley-III Scales of Infant and Toddler Development. Following 23 pilot scans, 216 children underwent scanning and T1-weighted images were obtained from 167/216 (77%) of children (median age 34.8 months). Furthermore, we found cortical surface area and thickness within frontal regions were associated with cognitive development, and in temporal and frontal regions with language development (beta coefficient ≥0.20). Overall, we demonstrate the feasibility of carrying out a neuroimaging study of young children during natural sleep in sub-Saharan Africa. Our findings indicate that dynamic morphological changes in heteromodal association regions are associated with cognitive and language development at this young age. These proof-of-concept analyses suggest similar links between the brain and cognition as prior literature from high income countries, enhancing understanding of the interplay between cortical structure and function during brain maturation.en_US
dc.identifier.citationWedderburn CJ, Subramoney S, Yeung S, Fouche JP, Joshi SH, Narr KL, Rehman AM, Roos A, Ipser J, Robertson FC, Groenewold NA, Gibb DM, Zar HJ, Stein DJ, Donald KA. Neuroimaging young children and associations with neurocognitive development in a South African birth cohort study. Neuroimage. 2020 Oct 1;219:116846. doi: 10.1016/j.neuroimage.2020.116846. Epub 2020 Apr 15.en_US
dc.identifier.doi10.1016/j.neuroimage.2020.116846
dc.identifier.journalNeuroImageen_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/32304884/
dc.identifier.urihttps://hdl.handle.net/11288/595652
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.research.unitRisk & Resilience in Mental Disordersen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectAfricaen_US
dc.subjectChildrenen_US
dc.subjectCognitionen_US
dc.subjectCortical surface areaen_US
dc.subjectCortical thicknessen_US
dc.subjectNeuroimagingen_US
dc.titleNeuroimaging young children and associations with neurocognitive development in a South African birth cohort studyen_US
dc.typeArticleen_US
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