IL-4Rα-expressing CD11c cells contribute to driving optimal cellular responses during Schistosoma mansoni infection in mice
Ndlovu, H Nono, J.K Nieuwenhuizen, N.E Brombacher, F
Ndlovu, H
Nono, J.K
Nieuwenhuizen, N.E
Brombacher, F
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Abstract
Development of IL-4 receptor alpha (IL-4Rα)-dependent cellular immunity regulates host protection against acute schistosomiasis. In this study, we investigated the importance of IL-4Rα-expressing CD11c cells in driving the development of optimal cellular responses to Schistosoma mansoni infection by using CD11c IL-4Rα BALB/c mice, which lacked IL-4Rα expression on dendritic cells and alveolar macrophages. Abrogation of IL-4Rα expression on CD11c cells affected activation of CD4 T cells, resulting in reduced numbers of effector CD4 T cells and impaired production of Th1 and Th2 cytokines by CD4 T cells ex vivo. However, secretion of both type 1 and type 2 Ab isotypes was unchanged in infected CD11c-specific IL-4Rα-deficient mice compared to littermate controls. Together, these data demonstrate that IL-4Rα-expressing CD11c cells play an important role in maintaining cellular immunity during schistosomiasis in mice.
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Date
2018-11-30
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Oxford Academic
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Keywords
CD11c+ cells,IL-4Rα,acute,immunity,mice,schistosomiasis
Citation
Ndlovu H, Nono JK, Nieuwenhuizen NE, Brombacher F. IL-4Rα-expressing CD11c+ cells contribute to driving optimal cellular responses during Schistosoma mansoni infection in mice. J Leukoc Biol. 2019 Feb;105(2):307-316. doi: 10.1002/JLB.MA0318-115R.