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Publication: Assessment of placental metal levels in a South African cohort
Meyrueix, L Adair, L Norris, S.A Ideraabdullah, F
Meyrueix, L
Adair, L
Norris, S.A
Ideraabdullah, F
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Abstract
The placenta plays an important role in mediating the effect of maternal metals exposure on fetal development, acting as both barrier and transporter. Term-placenta metals levels serve as an informative snapshot of maternal/fetal exposure during pregnancy and could be used to predict offspring short- and long-term health outcomes. Here, we measured term-placenta metal levels of 11 metals in 42 placentas from the Soweto First 1000 days cohort (S1000, Soweto-Johannesburg, SA).
We compared these placental metals concentrations to previously reported global cohort measurements to determine whether this cohort is at increased risk of exposure. Placental metals were tested for correlations to understand potential interactions between metals. Since these samples are from a birth cohort study, we also performed exploratory analyses to determine whether metals levels were associated with placenta and birth outcomes. Most S1000 placental metals levels were similar to other cohorts, however, cadmium (Cd) levels up to 50-fold lower, and essential elements nickel (Ni) and chromium (Cr) levels up to 6- and 16-fold lower, respectively. Cd, Se, and Ni were associated with placenta and birth outcomes. Studies are ongoing to examine underlying mechanisms and how these developmental differences affect long-term health.
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Date
2019-07-18
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Springer Nature
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Keywords
Metals,Placenta,Pregnancy,Birth outcomes,South Africa
Citation
Meyrueix L, Adair L, Norris SA, Ideraabdullah F. Assessment of placental metal levels in a South African cohort. Environ Monit Assess. 2019 Jul 18;191(8):500. doi: 10.1007/s10661-019-7638-2.