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Publication: IL-4 mediated resistance of BALB/c mice to visceral leishmaniasis is independent of IL-4Ralpha signaling via T cells
McFarlane, E Mokgethi, T Kaye, P.M Hurdayal, R Brombacher, F Alexander, J Carter, K.C
McFarlane, E
Mokgethi, T
Kaye, P.M
Hurdayal, R
Brombacher, F
Alexander, J
Carter, K.C
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Abstract
Previous studies infecting global IL-4Rα−/−, IL-4−/−, and IL-13−/−mice on a BALB/c background with the visceralizing parasite Leishmania donovani have shown that the T helper 2 cytokines, IL-4, and IL-13, play influential but not completely overlapping roles in controlling primary infection. Subsequently, using macrophage/neutrophil-specific IL-4Rα deficient BALB/c mice, we demonstrated that macrophage/neutrophil unresponsiveness to IL-4 and IL-13 did not have a detrimental effect during L. donovani infection. Here we expand on these findings and show that CD4+ T cell-(Lckcre), as well as pan T cell-(iLckcre) specific IL-4Rα deficient mice, on a BALB/c background, unlike global IL-4Rα deficient mice, are also not adversely affected in terms of resistance to primary infection with L. donovani.
Our analysis suggested only a transient and tissue specific impact on disease course due to lack of IL-4Rα on T cells, limited to a reduced hepatic parasite burden at day 30 post-infection. Consequently, the protective role(s) demonstrated for IL-4 and IL-13 during L. donovani infection are mediated by IL-4Rα-responsive cell(s) other than macrophages, neutrophils and T cells.
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2019-08-16
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Frontiers
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IL-4 mediated resistance,BALB/c Mice
Citation
McFarlane E, Mokgethi T, Kaye PM, Hurdayal R, Brombacher F, Alexander J and Carter KC. IL-4 mediated resistance of BALB/c mice to visceral leishmaniasis is independent of IL-4Ralpha signaling via T Cells. Frontiers in Immunology. 2019 Aug;10:1957. doi: 10.3389/fimmu.2019.01957