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SAMRC InfoSpace: Recent submissions
Now showing items 1-20 of 147
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Differential expression of glycoprotein IV on monocyte subsets following high-fat diet feeding and the impact of short-term low-dose aspirin treatment
(Elsevier, 2020-08-01)Objective: To assess the levels of glycoprotein GPIV (CD36) expression on peripheral blood monocyte subsets, in a mouse model of glucose intolerance. Moreover, to determine the effect of; low-dose aspirin (LDA) alone, LDA ... -
Identification of potential biomarkers for predicting the early onset of diabetic cardiomyopathy in a mouse model
(Nature Publishing Group, 2020-07-23)Type 2 diabetes (T2D) is characterized by metabolic derangements that cause a shift in substrate preference, inducing cardiac interstitial fibrosis. Interstitial fibrosis plays a key role in aggravating left ventricular ... -
Is diet partly responsible for differences in COVID‑19 death rates between and within countries?
(BMC, 2020-05-27)Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most current debates on ... -
Rubella vaccine introduction in the South African public vaccination schedule: Mathematical modelling for decision making
(MDPI, 2020-07-13)Background: age structured mathematical models have been used to evaluate the impact of rubella-containing vaccine (RCV) introduction into existing measles vaccination programs in several countries. South Africa has a ... -
Health worker experiences of and perspectives on engaging men in HIV care: A qualitative study in Cape Town, South Africa
(SAGE, 2020-05-29)Men generally fare worse than women across the HIV cascade. While we know much about how men perceive the health services, we know little about how health workers (HWs) themselves have experienced engaging with men and ... -
The effectiveness of peer and community health worker-led self-management support programs for improving diabetes health-related outcomes in adults in low-and-middle-income countries: A systematic review
(BMC, 2020-06-06)Objective: Community-based peer and community health worker-led diabetes self-management programs (COMP-DSMP) can benefit diabetes care, but the supporting evidence has been inadequately assessed. This systematic review ... -
Diverse genomoviruses representing twenty‑nine species identified associated with plants
(Springer, 2020)Genomoviruses (family Genomoviridae) are circular single-stranded DNA viruses that have been mainly identified through metagenomics studies in a wide variety of samples from various environments. Here, we describe 98 genomes ... -
Rosmarinic acid exhibits anticancer effects via MARK4 inhibition
(Nature Publishing Group, 2020-06-25)Microtubule affinity regulating kinase (MARK4) is a potential drug target for different types of cancer as it controls the early step of cell division. In this study, we have screened a series of natural compounds and ... -
A genomics network established to respond rapidly to public health threats in South Africa
(Elsevier, 2020)No abstract available. -
Effectiveness of reactive focal mass drug administration and reactive focal vector control to reduce malaria transmission in the low malaria-endemic setting of Namibia: A cluster-randomised controlled, open-label, two-by-two factorial design trial
(The Lancet, 2020-04-25)Background: In low malaria-endemic settings, screening and treatment of individuals in close proximity to index cases, also known as reactive case detection (RACD), is practised for surveillance and response. However, other ... -
An optimal diagnostic strategy for tuberculosis in hospitalized HIV-infected patients using GeneXpert MTB/RIF and alere determine TB LAM Ag
(American society for Microbiology, 2020-09-22)The diagnosis of tuberculosis (TB) in HIV-infected patients is challenging. Both a urinary lipoarabinomannan (LAM) test (Alere TB LAM) and GeneXpert-MTB/RIF (Xpert) are useful for the diagnosis of TB. However, how to ... -
Unspoken inequality: How COVID-19 has exacerbated existing vulnerabilities of asylum-seekers, refugees, and undocumented migrants in South Africa
(BMC, 2020-08-20)An estimated 2 million foreign-born migrants of working age (15-64) were living in South Africa (SA) in 2017. Structural and practical xenophobia has driven asylum-seekers, refugees, and undocumented migrants in SA to ... -
Linking LOXL2 to cardiac interstitial fibrosis
(MDPI, 2020-08-18)Cardiovascular diseases (CVDs) are the leading causes of death worldwide. CVD pathophysiology is often characterized by increased stiffening of the heart muscle due to fibrosis, thus resulting in diminished cardiac function. ... -
Differential RD-1-specific IFN-γ host responses to diverse Mycobacterium tuberculosis strains in HIV-uninfected persons may be explained by genotypic variation in the ESX-1 region
(Elsevier, 2020-04-21)Objectives: Between-person variability in T-cell-specific interferon-gamma release assay (IGRA) responses and discordance between IGRA test formats are poorly understood. Methods: We evaluated the IFN-γ responses ... -
Role of vaccines in preventing influenza in healthy children
(HMPG, 2021-03-02)The role of an influenza vaccine is to minimise illness and death. Vaccines provide good protection against influenza strains and significantly reduce time off work. However, the recommendation for use depends on the ... -
Inter-Comparison Campaign of Solar UVR Instruments under Clear Sky Conditions at Reunion Island (21◦S, 55◦E)
(MDPI, 2020-04-19)Measurement of solar ultraviolet radiation (UVR) is important for the assessment of potential beneficial and adverse impacts on the biosphere, plants, animals, and humans. Excess solar UVR exposure in humans is associated ... -
An implementation study of oral and blood-based HIV self-testing and linkage to care among men in rural and peri-urban KwaZulu-Natal, South Africa
(John Wiley and Sons, 2020-04-22)Introduction: In South Africa, men living with HIV are less likely than women to test and know their status (the first UNAIDS “90-90-90” target), and men have worse outcomes across the HIV care cascade. HIV self-testing ... -
Association of deworming with reduced eosinophilia: implications of HIV/AIDS and co-endemic diseases
(2003)Eosinophil counts in venous blood were monitored during a randomized controlled deworming trial (n = 155 children) that lasted for a year, and in a whole-school deworming programme (range 174-256 children) of 2 years' ... -
Fumonisin mycotoxins in human hair
(2003)This study shows for the first time the accumulation of fumonisin mycotoxins in human hair of population clusters exposed to contaminated maize, and thus the feasibility of human hair analysis for the assessment of past ... -
Association between arterial compliance and anthropometry of children from four ethnic groups in South Africa: the Thusa bana study
(2003)Aim: To investigate whether associations and differences exist regarding the arterial compliance, dietary intake and anthropometric parameters of children of four different ethnic groups in South Africa. Study design: In ...