Tshabalala, MIngram, CSchlaphoff, TBorrill, VChristoffels, APepper, M.S2024-08-112024-08-112018-04-23Tshabalala M, Ingram C, Schlaphoff T, Borrill V, Christoffels A, Pepper MS. Human Leukocyte Antigen-A, B, C, DRB1, and DQB1 Allele and Haplotype Frequencies in a Subset of 237 Donors in the South African Bone Marrow Registry. J Immunol Res. 2018 Apr 23;2018:2031571. doi: 10.1155/2018/2031571.10.1155/2018/2031571https://www.hindawi.com/journals/jir/2018/2031571/https://doi.org/10.1155/2018/2031571https://hdl.handle.net/11288/597123Human leukocyte antigen- (HLA-) A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 allele and haplotype frequencies were studied in a subset of 237 volunteer bone marrow donors registered at the South African Bone Marrow Registry (SABMR). Hapl-o-Mat software was used to compute allele and haplotype frequencies from individuals typed at various resolutions, with some alleles in multiple allele code (MAC) format. Four hundred and thirty-eight HLA-A, 235 HLA-B, 234 HLA-DRB1, 41 HLA-DQB1, and 29 HLA-C alleles are reported. The most frequent alleles were A∗02:02g (0.096), B∗07:02g (0.082), C∗07:02g (0.180), DQB1∗06:02 (0.157), and DRB1∗15:01 (0.072). The most common haplotype was A∗03:01g~B∗07:02g~C∗07:02g~DQB1∗06:02~DRB1∗15:01 (0.067), which has also been reported in other populations. Deviations from Hardy-Weinberg equilibrium were observed in A, B, and DRB1 loci, with C~DQB1 being the only locus pair in linkage disequilibrium. This study describes allele and haplotype frequencies from a subset of donors registered at SABMR, the only active bone marrow donor registry in Africa. Although the sample size was small, our results form a key resource for future population studies, disease association studies, and donor recruitment strategies.enAttribution 3.0 United Stateshttp://creativecommons.org/licenses/by/3.0/us/Bone marrow transplantationGenotypeHLA-B antigensSouth AfricaSDG-03 Good health and well-beingArticleJournal of Immunology Research