FitzPatrick, L.MHawkins, K.EDelhove, J.M.K.MFernandez, ESoldati, CBullen, L.FNohturfft, AWaddington, S.NMedina, D.LBolaños, J.PMcKay, T.R2024-08-112024-08-112018-06-05FitzPatrick LM, Hawkins KE, Delhove JMKM, Fernandez E, Soldati C, Bullen LF, Nohturfft A, Waddington SN, Medina DL, Bolaños JP, McKay TR. NF-κB Activity Initiates Human ESC-Derived Neural Progenitor Cell Differentiation by Inducing a Metabolic Maturation Program. Stem Cell Reports. 2018 Jun 5;10(6):1766-1781. doi: 10.1016/j.stemcr.2018.03.015.https://doi.org/10.1016/j.stemcr.2018.03.015https://www.sciencedirect.com/science/article/pii/S2213671118301425?via%3Dihubhttps://hdl.handle.net/11288/597203Human neural development begins at embryonic day 19 and marks the beginning of organogenesis. Neural stem cells in the neural tube undergo profound functional, morphological, and metabolic changes during neural specification, coordinated by a combination of exogenous and endogenous cues. The temporal cell signaling activities that mediate this process, during development and in the postnatal brain, are incompletely understood. We have applied gene expression studies and transcription factor-activated reporter lentiviruses during in vitro neural specification of human pluripotent stem cells. We show that nuclear factor κB orchestrates a multi-faceted metabolic program necessary for the maturation of neural progenitor cells during neurogenesis.enAttribution 3.0 United Stateshttp://creativecommons.org/licenses/by/3.0/us/NF-κB signalingMetabolismAutophagyCell cycleHuman embryonic developmentNeurogenesisArticleStem Cell Reports