Taku, O.Mbulawa, Z.Z.A.Phohlo, K.Garcia-Jardon, M.Businge, C.B.Williamson, A.2024-05-182024-05-182021-02-11Taku O, Mbulawa ZZA, Phohlo K, Garcia-Jardon M, Businge CB, Williamson A-L. Distribution of Human Papillomavirus (HPV) Genotypes in HIV-Negative and HIV-Positive Women with Cervical Intraepithelial Lesions in the Eastern Cape Province, South Africa. Viruses. 2021; 13(2):280. https://doi.org/10.3390/v1302028010.3390/v13020280https://www.mdpi.com/1999-4915/13/2/280https://doi.org/10.3390/v13020280https://hdl.handle.net/11288/596151South African women have a high rate of cervical cancer cases, but there are limited data on human papillomavirus (HPV) genotypes in cervical intraepithelial neoplasia (CIN) in the Eastern Cape province, South Africa. A total of 193 cervical specimens with confirmed CIN from women aged 18 years or older, recruited from a referral hospital, were tested for HPV infection. The cervical specimens, smeared onto FTA cards, were screened for 36 HPV types using an HPV direct flow kit. HPV prevalence was 93.5% (43/46) in CIN2 and 96.6% (142/147) in CIN3. HIV-positive women had a significantly higher HPV prevalence than HIV-negative women (98.0% vs. 89.1%, p = 0.012). The prevalence of multiple types was significantly higher in HIV-positive than HIV-negative women (p = 0.034). The frequently detected genotypes were HPV35 (23.9%), HPV58 (23.9%), HPV45 (19.6%), and HPV16 (17.3%) in CIN2 cases, while in CIN3, HPV35 (22.5%), HPV16 (21.8%), HPV33 (15.6%), and HPV58 (14.3%) were the most common identified HPV types, independent of HIV status. The prevalence of HPV types targeted by the nonavalent HPV vaccine was 60.9% and 68.7% among women with CIN2 and CIN3, respectively, indicating that vaccination would have an impact both in HIV-negative and HIV-positive South African women, although it will not provide full protection in preventing HPV infection and cervical cancer lesions.enAttribution 3.0 United Stateshttp://creativecommons.org/licenses/by/3.0/us/South AfricaCervical intraepithelial lesionsHuman immunodeficiency virusHuman papillomavirusHuman immunodeficiency virusArticleViruses