Carvalho, A.FStubbs, BVancampfort, DKloiber, SMaes, MFirth, JKurdyak, P.AStein, D.JRehm, JKoyanagi, A2024-12-292024-12-292018-11-15Carvalho AF, Stubbs B, Vancampfort D, Kloiber S, Maes M, Firth J, Kurdyak PA, Stein DJ, Rehm J, Koyanagi A. Cannabis use and suicide attempts among 86,254 adolescents aged 12-15 years from 21 low- and middle-income countries. Eur Psychiatry. 2019 Feb;56:8-13. doi: 10.1016/j.eurpsy.2018.10.006.10.1016/j.eurpsy.2018.10.006https://pubmed.ncbi.nlm.nih.gov/30447436/https://doi.org/10.1017/neu.2018.28https://hdl.handle.net/11288/597959Background: Evidence suggests that cannabis use may be associated with suicidality in adolescence. Nevertheless, very few studies have assessed this association in low- and middle-income countries (LMICs). In this cross-sectional survey, we investigated the association of cannabis use and suicidal attempts in adolescents from 21 LMICs, adjusting for potential confounders. Method: Data from the Global school-based Student Health Survey was analyzed in 86,254 adolescents from 21 countries [mean (SD) age = 13.7 (0.9) years; 49.0% girls]. Suicide attempts during past year and cannabis during past month and lifetime were assessed. Multivariable logistic regression analyses were conducted. Results: The overall prevalence of past 30-day cannabis use was 2.8% and the age-sex adjusted prevalence varied from 0.5% (Laos) to 37.6% (Samoa), while the overall prevalence of lifetime cannabis use was 3.9% (range 0.5%-44.9%). The overall prevalence of suicide attempts during the past year was 10.5%. Following multivariable adjustment to potential confounding variables, past 30-day cannabis use was significantly associated with suicide attempts (OR = 2.03; 95% CI: 1.42-2.91). Lifetime cannabis use was also independently associated with suicide attempts (OR = 2.30; 95% CI: 1.74-3.04). Conclusion: Our data indicate that cannabis use is associated with a greater likelihood for suicide attempts in adolescents living in LMICs. The causality of this association should be confirmed/refuted in prospective studies to further inform public health policies for suicide prevention in LMICs.en© 2018 Elsevier Masson SAS. All rights reserved.https://www.cambridge.org/core/termsarticle1778-3585S0924933800009093