Comparison of amplicor and GeneXpert MTB/RIF tests for diagnosis of tuberculous meningitis.

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Date
2014-10
Author
Patel, Vinod B
Connolly, Cathy
Singh, Ravesh
Lenders, Laura
Matinyenya, Brian
Theron, Grant
Ndung'u, Thumbi
Dheda, Keertan
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Abstract
There are no data about the comparative accuracy of commercially available nucleic acid amplification tests (GeneXpert MTB/RIF and Roche Amplicor) for the diagnosis of tuberculous meningitis (TBM). A total of 148 patients with suspected TBM were evaluated, and cultures served as the reference standard. The sensitivities and specificities (95% confidence interval [CI]) for the Amplicor and Xpert MTB/RIF tests were similar: 46 (31-60) versus 50 (33-67) and 99 (93-100) and 94 (84-99), respectively.
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http://hdl.handle.net/11288/595134
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