Comparison of amplicor and GeneXpert MTB/RIF tests for diagnosis of tuberculous meningitis.
Date
2014-10Author
Patel, Vinod B
Connolly, Cathy
Singh, Ravesh
Lenders, Laura
Matinyenya, Brian
Theron, Grant
Ndung'u, Thumbi
Dheda, Keertan
Metadata
Show full item recordAbstract
There are no data about the comparative accuracy of commercially available nucleic acid amplification tests (GeneXpert MTB/RIF and Roche Amplicor) for the diagnosis of tuberculous meningitis (TBM). A total of 148 patients with suspected TBM were evaluated, and cultures served as the reference standard. The sensitivities and specificities (95% confidence interval [CI]) for the Amplicor and Xpert MTB/RIF tests were similar: 46 (31-60) versus 50 (33-67) and 99 (93-100) and 94 (84-99), respectively.