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Comparison of amplicor and GeneXpert MTB/RIF tests for diagnosis of tuberculous meningitis.
Comparison of amplicor and GeneXpert MTB/RIF tests for diagnosis of tuberculous meningitis.
Patel, Vinod B Connolly, Cathy Singh, Ravesh Lenders, Laura Matinyenya, Brian Theron, Grant Ndung'u, Thumbi Dheda, Keertan
Patel, Vinod B
Connolly, Cathy
Singh, Ravesh
Lenders, Laura
Matinyenya, Brian
Theron, Grant
Ndung'u, Thumbi
Dheda, Keertan
Abstract
There are no data about the comparative accuracy of commercially available nucleic acid amplification tests (GeneXpert MTB/RIF and Roche Amplicor) for the diagnosis of tuberculous meningitis (TBM). A total of 148 patients with suspected TBM were evaluated, and cultures served as the reference standard. The sensitivities and specificities (95% confidence interval [CI]) for the Amplicor and Xpert MTB/RIF tests were similar: 46 (31-60) versus 50 (33-67) and 99 (93-100) and 94 (84-99), respectively.
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Date
2014-10
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Keywords
Tuberculous Meningitis , Diagnosis , GeneXpert MTB/RIF , Roche Amplicor , accuracy
Citation
Comparison of amplicor and GeneXpert MTB/RIF tests for diagnosis of tuberculous meningitis. 2014, 52 (10):3777-80 J. Clin. Microbiol.