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dc.contributor.authorJooste, P.L.
dc.contributor.authorWeight, M.J.
dc.contributor.authorKriek, J.A.
dc.contributor.authorLouw, A.J.
dc.date.accessioned2020-05-25T10:01:54Z
dc.date.available2020-05-25T10:01:54Z
dc.date.issued1999
dc.identifier.citationJooste PL, Weight MJ, Kriek JA, Louw AJ. Endemic goitre in the absence of iodine deficiency in schoolchildren of the Northern Cape Province of South Africa. European journal of clinical nutritionen_US
dc.identifier.issn0954-3007
dc.identifier.urihttps://infospace.mrc.ac.za/handle/11288/595237
dc.description.abstractObjective: The study was undertaken to investigate whether endemic goitre still exists in the Northern Cape Province of South Africa more than 55 years after it was reported and, if so, whether iodine deficiency, or fluoride in the drinking water, is linked to the goitres. Design: Cross-sectional study of children in three pairs of towns. Subjects: The 6-, 12- and 15-year-old children (n = 671) who had been lifetime residents in two Northern Cape towns with low levels, two towns with near optimal levels and two towns with high levels of fluoride in the drinking water were recruited through the schools as study participants. Results: Endemic goitre was found in all the towns except one, ranging from 5% to 29%. Iodine deficiency did not prevail in the study area because the median urinary iodine concentration, exceeding 1.58 micromol/l in all but one of the towns, indicated a more than adequate iodine consumption. The drinking water and, to a lesser extent, iodised salt were important sources of iodine. No relationship was found between fluoride in the water and the mild goitre prevalence (5% to 18%) in the four towns with either a low or near optimal fluoride content in the water. The causal factor(s) responsible for the goitres in these four towns were not clear from our data. However, the prevalence of goitre was higher (28% and 29%) in the two towns with high levels of fluoride in the water. Conclusion: These results indicate that either a high fluoride level in the water or another associated goitrogen, other than iodine deficiency, may have been responsible for these goitres.en_US
dc.description.sponsorshipThe headmasters, staff and children of the schools are thanked for their wholehearted collaboration in this study. We also thank Mr De Wet Marais for performing the urinary iodine analyses.en_US
dc.language.isoenen_US
dc.publisherBasingstoke: Nature Publishingen_US
dc.relation.urlhttp://pascal-francis.inist.fr/vibad/index.php?action=search&terms=1658058 .en_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectNutrition, obesity, metabolic disordersen_US
dc.subjectBiological and medical sciencesen_US
dc.subjectMedical sciencesen_US
dc.subjectEndocrinopathiesen_US
dc.subjectThyroid. Thyroid axis (diseases)en_US
dc.subjectNon tumoral diseases. Target tissue resistance. Benign neoplasmsen_US
dc.subjectTropical medicineen_US
dc.subjectEndocrinopathyen_US
dc.subjectHumanen_US
dc.subjectThyroid diseasesen_US
dc.subjectSchool ageen_US
dc.subjectDeficiencyen_US
dc.subjectChilden_US
dc.subjectEtiologyen_US
dc.subjectIodineen_US
dc.subjectPrevalenceen_US
dc.titleEndemic goitre in the absence of iodine deficiency in schoolchildren of the Northern Cape Province of South Africaen_US
dc.typeArticleen_US
dc.contributor.departmentNational Research Programme for Nutritional Intervention, Medical Research Councilen_US
dc.identifier.journalEuropean Journal of Clinical Nutritionen_US
dc.research.unitClosed Unitsen_US
dc.date.epub1999


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Attribution 3.0 United States
Except where otherwise noted, this item's license is described as Attribution 3.0 United States