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dc.contributor.authorRahbeeni, F.
dc.contributor.authorHendrikse, A.S.
dc.contributor.authorSmuts, C.M.
dc.contributor.authorGelderblom, W.C.A.
dc.contributor.authorAbel, S.
dc.contributor.authorBlekkenhorst, G.H.
dc.date.accessioned2020-06-26T12:44:56Z
dc.date.available2020-06-26T12:44:56Z
dc.date.issued2000
dc.identifier.citationRAHBEENI F, HENDRIKSE AS, SMUTS CM, GELDERBLOM WCA, ABEL S, BLEKKENHORST GH. The effect of evening primrose oil on the radiation response and blood flow of mouse normal and tumour tissue. International journal of radiation biology (Printen_US
dc.identifier.issn0955-3002.
dc.identifier.urihttps://infospace.mrc.ac.za/handle/11288/595244
dc.description.abstractPurpose: To investigate the effect of the oral administration of evening primrose oil on the radiation response and the blood flow of normal tissue and a tumour in BALB/c mice. Methods and materials: Aliquots of evening primrose oil were fed to BALB/c mice daily and the radiation response of the skin was assessed by the determination of ED50 values for the incidence of moist desquamation, using probit analysis. Tumour radiosensitivity was investigated by determining the growth delay caused by irradiation of a transplantable rhabdomyosarcoma. The 86RbCl uptake technique was used to determine the blood flow in normal foot and tumour tissue. The fatty-acid content of red blood cells, plasma and tumour tissue was measured using gas chromatography. Results: Daily evening primrose oil dietary supplementation reduced the sensitivity of skin to radiation-induced moist desquamation and prevented the radiation-associated increase in blood flow that was observed in this tissue. No modification of tumour blood flow or of tumour sensitivity to radiation resulted from evening primrose oil supplementation of mice. Evening primrose oil supplementation resulted in changes in plasma levels of linoleic acid (LA), gamma-linolenic acid (GLA), dihomo-gamma-linolenic acid (DGLA) and arachidonic acid (AA). These changes were contingent on whether the mice had been irradiated or not. In red blood cells evening primrose oil supplementation increased the GLA level of unirradiated mice and the LA level at 20 days after irradiation. There were no changes in tumour fatty-acid levels as a result of evening primrose oil treatment. Conclusions: Daily evening primrose oil supplementation reduced the sensitivity of skin to radiation-induced moist desquamation but did not alter tumour sensitivity to radiation.en_US
dc.description.sponsorshipThe authors are grateful for the financial support received from the Harry Crossley Fund and the Cancer Association of South Africa, and to Martelle Marais for her technical assistance.en_US
dc.language.isoenen_US
dc.publisherTaylor and Francisen_US
dc.relation.urlhttp://pascal-francis.inist.fr/vibad/index.php?action=search&terms=1395296 .en_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectMedical oncologyen_US
dc.subjectBiological and Medical Sciencesen_US
dc.subjectBiomedical engineeringen_US
dc.subjectTissues, organs and organisms biophysicsen_US
dc.subjectBiological effects of radiationen_US
dc.subjectAnimalen_US
dc.subjectBlood flowen_US
dc.subjectEvening primrose oilen_US
dc.subjectHemodynamicsen_US
dc.subjectRadiosensitivityen_US
dc.subjectMouseen_US
dc.subjectTumoral tissueen_US
dc.subjectTissueen_US
dc.subjectOral administrationen_US
dc.titleThe effect of evening primrose oil on the radiation response and blood flow of mouse normal and tumour tissueen_US
dc.typeArticleen_US
dc.contributor.departmentProgramme on Mycotoxins and Experimental Carcinogenesis, Tygerberg, South Africa.en_US
dc.identifier.journalInternational journal of radiation biologyen_US
dc.research.unitClosed Unitsen_US
dc.date.epub2000


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Attribution 3.0 United States
Except where otherwise noted, this item's license is described as Attribution 3.0 United States