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dc.contributor.authorAdams, J.F.
dc.contributor.authorSchölvinck, E.H.
dc.contributor.authorGie, R.P.
dc.contributor.authorPotter, P.C.
dc.contributor.authorBeyers, N.
dc.contributor.authorBeyers, A.D.
dc.identifier.citationAdams J, Scholvinck E, Gie R, Potter P, Beyers N, Beyers A. Decline in total serum IgE after treatment for tuberculosis. The Lanceten_US
dc.description.abstractBackground: Infection with Mycobacterium tuberculosis induces a type-1 immune response, whereas intestinal parasites elicit a type-2 response. Given that type-1 and type-2 responses inhibit each other, we investigated if M tuberculosis downregulates serum IgE, a marker of a type-2 response. Methods: A prospective study was done in the Western Cape Province of South Africa, where tuberculosis and intestinal-parasite infection are common. Total serum IgE was determined for 37 controls and for 33 adolescent patients at presentation with tuberculosis and after successful completion of treatment. IgE specific for ascaris and allergens were measured in a subset of these individuals. Mantoux skin tests were done on 35 controls and on 31 patients at diagnosis. Findings: Total IgE concentrations were high in controls (mean 313 kU/L) and in patients before treatment (mean 457 kU/L, p=0.085) and declined in all patients following successful treatment (mean 175 kU/L, p<0.0001). Posttreatment IgE concentrations did not differ from concentrations in controls. Ascaris-specific IgE was lower in controls (mean 1.73 kU/L) than in patients before treatment (4.62 kU/L, p=0.023) and was 2.39 kU/L in patients after treatment (p=0.0625). Tuberculin induration correlated inversely with IgE in patients but not in controls. Interpretation: Infection with M tuberculosis as such is not incompatible with a prominent IgE response. IgE concentrations decreased after successful treatment of tuberculosis, showing that IgE concentrations in human beings can be downregulated under these circumstances, presumably due to enhancement of a type-1 response.en_US
dc.description.sponsorshipWe would like to thank the field workers, particularly Danite Bester and Mirna van Aardt, for dedicated care of patients in the study community. We thank Magda Schinkel for determination of specific IgE concentrations, Theunis Kotze for statistical advice, and Ivan Toms, Head of Health, City of Tygerberg, for permission to publish. Reagents for CAP RAST tests were supplied by Pharmacia, Uppsala, Sweden. The work was supported by the Glaxo Wellcome Action TB programme. A D Beyers was a Wellcome Trust senior research fellow in South Africa. E H Schölvinck is a recipient of a grant from the Willem Bakhuys Roozeboom Stichting.en_US
dc.rightsAttribution 3.0 United States*
dc.subjectImmunoglobulin E -- Health aspectsen_US
dc.subjectTuberculosis -- Drug therapyen_US
dc.subjectTuberculosis -- Preventionen_US
dc.subjectTuberculosis -- Research.en_US
dc.titleDecline in total serum IgE after treatment for tuberculosis.en_US
dc.contributor.departmentCentre for Molecular and Cellular Biology and Department of Medical Biochemistry, University of Stellenbosch Medical School, Tygerberg, South Africa.en_US
dc.identifier.journalThe Lanceten_US
dc.research.unitClosed Unitsen_US

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Attribution 3.0 United States
Except where otherwise noted, this item's license is described as Attribution 3.0 United States