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dc.contributor.authorSchoeman S.E.
dc.contributor.authorMarkus M.B.
dc.contributor.authorBentwich Z.
dc.contributor.authorMansvelt E.P.G.
dc.contributor.authorAdams V.J.
dc.contributor.authorFincham J.E.
dc.contributor.authorDhansay M.A.
dc.contributor.authorLombard, C.J.
dc.date.accessioned2020-09-10T09:36:34Z
dc.date.available2020-09-10T09:36:34Z
dc.date.issued2003
dc.identifier.citationSchoeman S.E., Markus M.B., Bentwich Z., Mansvelt E.P.G., Adams V.J., Fincham J.E., et al. Association of deworming with reduced eosinophilia : implications for HIV / AIDS and co-endemic diseases : research letters. South African Journal of Scienceen_US
dc.identifier.issn0038-2353
dc.identifier.issn1996-7489.
dc.identifier.urihttps://infospace.mrc.ac.za/handle/11288/595279
dc.description.abstractEosinophil counts in venous blood were monitored during a randomized controlled deworming trial (n = 155 children) that lasted for a year, and in a whole-school deworming programme (range 174-256 children) of 2 years' duration. Mean eosinophil counts (×109 / l) decreased from 0.70 in the randomized trial, and 0.61 in the whole-school study, to well within the normal paediatric range of 0.05-0.45 (P < 0.05). The prevalence of eosinophilia declined from 57% to 37% in the randomized trial (mean for 400, 800 and 1200 mg albendazole doses); and from 47% to 24% in the whole-school study (500 mg stat mebendazole). Benzimidazole anthelminthics were highly effective against Ascaris but less so against Trichuris. Activated eosinophils are effector and immunoregulatory leucocytes of the T-helper cell type 2 (Th2) immune response to parasitic helminths and atopic disorders. Under conditions of poverty where soil-transmitted helminths are hyperendemic, Th2 polarization of the immune profile is characteristic. Regular anthelminthic treatment should reduce contact with worm antigens, and this may contribute to re-balancing of the immune profile. Suppression of eosinophil recruitment and activation, together with related cellular and molecular immunological changes, might have positive implications for prevention and treatment of co-endemic diseases, including HIV / AIDS, cholera, tuberculosis and atopic disorders..en_US
dc.language.isoenen_US
dc.relation.urlhttp://hdl.handle.net/10520/EJC97605.en_US
dc.relation.urlhttp://journals.co.za/content/sajsci/99/3-4/EJC97605en_US
dc.relation.urlhttp://journals.co.za/content/sajsci/99/3-4/EJC97605?crawler=true.en_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectDewormingen_US
dc.subjecteosinophiliaen_US
dc.subjectcellen_US
dc.subjectimmuneen_US
dc.subjectimplicationsen_US
dc.subjectco-endemic diseasesen_US
dc.subjectHIV / AIDSen_US
dc.titleAssociation of deworming with reduced eosinophilia: implications of HIV/AIDS and co-endemic diseasesen_US
dc.typeArticleen_US
dc.contributor.departmentMedical Research Council, P O Box 19070, South Africaen_US
dc.identifier.journalSouth African Journal of South Africaen_US
dc.research.unitClosed Unitsen_US
dc.date.epub2003


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Attribution 3.0 United States
Except where otherwise noted, this item's license is described as Attribution 3.0 United States