Association of deworming with reduced eosinophilia: implications of HIV/AIDS and co-endemic diseases
dc.contributor.author | Schoeman S.E. | |
dc.contributor.author | Markus M.B. | |
dc.contributor.author | Bentwich Z. | |
dc.contributor.author | Mansvelt E.P.G. | |
dc.contributor.author | Adams V.J. | |
dc.contributor.author | Fincham J.E. | |
dc.contributor.author | Dhansay M.A. | |
dc.contributor.author | Lombard, C.J. | |
dc.contributor.department | Medical Research Council, P O Box 19070, South Africa | en_US |
dc.date.accessioned | 2020-09-10T09:36:34Z | |
dc.date.available | 2020-09-10T09:36:34Z | |
dc.date.epub | 2003 | |
dc.date.issued | 2003 | |
dc.description.abstract | Eosinophil counts in venous blood were monitored during a randomized controlled deworming trial (n = 155 children) that lasted for a year, and in a whole-school deworming programme (range 174-256 children) of 2 years' duration. Mean eosinophil counts (×109 / l) decreased from 0.70 in the randomized trial, and 0.61 in the whole-school study, to well within the normal paediatric range of 0.05-0.45 (P < 0.05). The prevalence of eosinophilia declined from 57% to 37% in the randomized trial (mean for 400, 800 and 1200 mg albendazole doses); and from 47% to 24% in the whole-school study (500 mg stat mebendazole). Benzimidazole anthelminthics were highly effective against Ascaris but less so against Trichuris. Activated eosinophils are effector and immunoregulatory leucocytes of the T-helper cell type 2 (Th2) immune response to parasitic helminths and atopic disorders. Under conditions of poverty where soil-transmitted helminths are hyperendemic, Th2 polarization of the immune profile is characteristic. Regular anthelminthic treatment should reduce contact with worm antigens, and this may contribute to re-balancing of the immune profile. Suppression of eosinophil recruitment and activation, together with related cellular and molecular immunological changes, might have positive implications for prevention and treatment of co-endemic diseases, including HIV / AIDS, cholera, tuberculosis and atopic disorders.. | en_US |
dc.identifier.citation | Schoeman S.E., Markus M.B., Bentwich Z., Mansvelt E.P.G., Adams V.J., Fincham J.E., et al. Association of deworming with reduced eosinophilia : implications for HIV / AIDS and co-endemic diseases : research letters. South African Journal of Science | en_US |
dc.identifier.issn | 0038-2353 | |
dc.identifier.issn | 1996-7489. | |
dc.identifier.journal | South African Journal of South Africa | en_US |
dc.identifier.uri | https://infospace.mrc.ac.za/handle/11288/595279 | |
dc.language.iso | en | en_US |
dc.relation.url | http://hdl.handle.net/10520/EJC97605. | en_US |
dc.relation.url | http://journals.co.za/content/sajsci/99/3-4/EJC97605 | en_US |
dc.relation.url | http://journals.co.za/content/sajsci/99/3-4/EJC97605?crawler=true. | en_US |
dc.research.unit | Closed Units | en_US |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject | Deworming | en_US |
dc.subject | eosinophilia | en_US |
dc.subject | cell | en_US |
dc.subject | immune | en_US |
dc.subject | implications | en_US |
dc.subject | co-endemic diseases | en_US |
dc.subject | HIV / AIDS | en_US |
dc.title | Association of deworming with reduced eosinophilia: implications of HIV/AIDS and co-endemic diseases | en_US |
dc.type | Article | en_US |
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