Fumonisin mycotoxins in human hair

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dc.contributor.authorSewram, V.
dc.contributor.authorMshicilelo, N.
dc.contributor.authorShephard, G.S.
dc.contributor.authorMarasas, W.F.O
dc.contributor.departmentPromec Unit, Medical Research Council, PO Box 19070, Tygerberg, 7505, South Africa.en_US
dc.date.accessioned2020-09-10T09:31:08Z
dc.date.available2020-09-10T09:31:08Z
dc.date.epub2003
dc.date.issued2003
dc.description.abstractThis study shows for the first time the accumulation of fumonisin mycotoxins in human hair of population clusters exposed to contaminated maize, and thus the feasibility of human hair analysis for the assessment of past fumonisin exposure. Composite hair samples were obtained from the Bizana, Butterworth and Centane districts within the Transkei region of the Eastern Cape Province of South Africa. Following methanol extraction and strong anion exchange clean up, the fumonisins FB1, FB2 and FB3 were detected using high performance liquid chromatography coupled to electrospray ionization-mass spectrometry (HPLC-ESI-MS). Hair from Centane and Butterworth showed mean levels of FB1 of 26.7 and 23.5 μg kg-1 hair, respectively. FB2 was only detected in hair from Centane and in one sampling point in Butterworth, with mean levels of 6.5 and 5.7 μg kg-1 hair, respectively. Hair samples from Bizana, on the other hand, were found to contain higher levels of FB1 (mean 33.0 μg kg-1 hair) and FB2 (mean 11.1 μg kg-1 hair). No samples contained more than trace levels of FB3. Recoveries from spiked hair samples using this method ranged from 81% to 101%, demonstrating the applicability of hair analysis in assessing human exposure to fumonisin mycotoxins..en_US
dc.description.sponsorshipWe gratefully acknowledge Ms N. I. M. Somdyala for assisting in the collection of hair, Dr H. F. Vismer for assistance with assessing the bacterial and fungal growth on the hair samples, and Ms P. Snijman for isolation of the fumonisins from cultures.en_US
dc.identifier.citationSEWRAM V, MSHICILELI N, SHEPHARD GS, MARASAS WFO. Fumonisin mycotoxins in human hair. Biomarkers (London Print)en_US
dc.identifier.issn1354-750X.
dc.identifier.journalBiomarkersen_US
dc.identifier.urihttps://infospace.mrc.ac.za/handle/11288/595278
dc.language.isoenen_US
dc.relation.urlhttp://pascal-francis.inist.fr/vibad/index.php?action=search&terms=14785317 .en_US
dc.research.unitClosed Unitsen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectEnvironmenten_US
dc.subjectEcologyen_US
dc.subjectToxicologyen_US
dc.subjectBiological and medical sciencesen_US
dc.subjectMedical sciencesen_US
dc.subjectToxicologyen_US
dc.subjectPlant poisons toxicologyen_US
dc.subjectFungien_US
dc.subjectToxinen_US
dc.subjectFooden_US
dc.subjectHair (head)en_US
dc.subjectFumonisinen_US
dc.subjectHumanen_US
dc.subjectBiological markeren_US
dc.subjectMycotoxinen_US
dc.subjectRateen_US
dc.subjectbiomarkeren_US
dc.subjectchronic exposureen_US
dc.subjecthuman hairen_US
dc.titleFumonisin mycotoxins in human hairen_US
dc.typeArticleen_US
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