An assessment of adverse drug reactions among HIV positive patients receiving antiretroviral treatment in South Africa.

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dc.contributor.authorMasenyetse, Lieketseng Jen
dc.contributor.authorManda, Samuel Omen
dc.contributor.authorMwambi, Henry Gen
dc.date.accessioned2016-01-28T10:38:47Zen
dc.date.available2016-01-28T10:38:47Zen
dc.date.epub2015-03-05en
dc.date.issued2015en
dc.description.abstractAntiretroviral treatment (ART) has been effective in reducing HIV/AIDS related morbidity and mortality. However, the use and uptake of ART has resulted in adverse reactions, due mainly to the medicine's toxicity and interactions with other medicines. The timing of adverse drug reactions (ADRs) among these patients is a critical public health issue for antiretroviral (ARV) treatment adherence and retention. Reliable monitoring of HIV patients on ART is through a structured pharmacovigilance surveillance system. However, recurrent nature of these data pose challenges in their analyses. This study aimed at modelling the timing of ADR events in HIV patients on ART using correlated time-to-event models.en
dc.description.sponsorshipThe original study on which the present article is based received financial support from the South African Field Epidemiology and Laboratory Training Programme (SAFELTP) funded by the Centers for Disease Control and Prevention (CDC). The Foundation for Professional Development (FPD) contributed to the development and maintenance of the database. SAFELTP, CDC and FPD had no role in the analysis, interpretation and preparation of the present article.en
dc.identifier.citationAn assessment of adverse drug reactions among HIV positive patients receiving antiretroviral treatment in South Africa. 2015, 12:6 AIDS Res Theren
dc.identifier.doi10.1186/s12981-015-0044-0en
dc.identifier.issn1742-6405en
dc.identifier.journalAIDS research and therapyen
dc.identifier.pmid25745501en
dc.identifier.urihttp://hdl.handle.net/11288/595142en
dc.language.isoenen
dc.relation.urlhttp://aidsrestherapy.biomedcentral.com/articles/10.1186/s12981-015-0044-0en
dc.research.unitBiostatistics Uniten
dc.rightsArchived with thanks to AIDS research and therapyen
dc.subjectAntiretroviral treatmenten
dc.subjectAdverse drug reactionsen
dc.subjectRecurrent eventsen
dc.subjectSouth Africaen
dc.titleAn assessment of adverse drug reactions among HIV positive patients receiving antiretroviral treatment in South Africa.en
dc.typeArticleen
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